Irbesartan/Hydrochlorothiazide 300/12.5 mg
What Irbesartan/Hydrochlorothiazide is used for:
- It is a combination of Irbesartan, an angiotensin II receptor antagonist, and Hydrochlorothiazide, a thiazide diuretic, indicated for hypertension:
- In patients not adequately controlled with monotherapy.
- As initial therapy in patients likely to need multiple drugs to achieve their blood pressure goal.
Do not take Irbesartan/Hydrochlorothiazide if:
- Hypersensitivity to Irbesartan or hydrochlorothiazide
- Hypersensitivity to sulfonamide-derived drugs (like sulfamethoxazole/trimethoprim, sulfasalazine)
- Anuria present (not enough urine production)
- Renal impairment
- Liver impairment
Warnings & Precautions:
- Talk to your doctor or pharmacist before taking Irbesartan/Hydrochlorothiazide
- To monitor kidney functions
- To monitor potassium levels
- If you have vision problems like myopia or glaucoma
- If you have lupus
- If you are at risk to be volume depleted (dehydrated)
Possible Side Effects:
- Fatigue
- Dizziness
- Muscle pain
Other medicines and Irbesartan/hydrochlorothiazide:
- Tell your doctor or pharmacist about all medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.
- Increased risk of kidney damage and reduction of its effects when taken with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and COX-2 inhibitors (like ibuprofen, ketoprfen, celecoxib)
- Increased risk of lithium toxicity when taken together
- Not recommended use with potassium supplements to avoid increase of potassium levels in blood.
With only Hydrochlorothiazide:
- Avoid cholestyramine and colestipol to have maximum absorption
- Adjust dose of antidiabetics
- Monitor while using alcohol, barbiturates and narcotics because of the potential hypotension
How to take Irbesartan/hydrochlorothiazide:
- Adults above 18 years of age and CrCl >30ml/min:
- The usual dose is: 1 tablet daily
- Irbesartan//hydrochlorothiazide tablet can be taken with or without food
- It may be administered with other antihypertensive agents
- It can be taken any time of the day
- Do not break the tablet in half
- Correct if known volume depletion prior to starting the medicine
How to store Irbesartan/hydrochlorothiazide:
- Keep this medicine out of the sight and reach of children.
- Store at Room Temperature [77°F (25°C)].
- Do not store above 30°
